The Diabetes Prevention Program Outcomes Study (DPPOS) is a multi-center clinical trial aimed at identifying long-term effects of diabetes intervention. It is the twelve year follow-up of the original Diabetes Prevention Program (DPP).
DPP evaluated an intensive lifestyle intervention and the diabetes medicine metformin in adults at high-risk for developing Type-2 Diabetes. Adults from groups predisposed to developing Type-2 Diabetes were asked to participate, including: African Americans, Asian Americans, Hispanic Americans, Pacific Islanders, and American Indians.
The initial study revealed a 58% reduction in risk of diabetes with lifestyle intervention practices and a 31% reduction in risk of diabetes with metformin intervention, when compared to a placebo group.
Twelve years later, DPPOS has been designed to find out if the DPP lifestyle and metformin treatments help prevent the complications of diabetes. The Southwest American Indian Center follows American Indian DPPOS participants in greater Phoenix, Arizona; in Shiprock, New Mexico; and in Zuni, New Mexico.