grade_logo150The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) is a long-term study of different treatments for Type-2 Diabetes.

The Southwest American Indian Center, located on the campus of the Phoenix Indian Health Center on North 16th St. in Phoenix, Arizona, is looking to work with people of Native American ancestry who have been diagnosed with Type-2 Diabetes within the past five years in order to find the best medicinal diabetes treatments. Many medications are available to treat Type-2 Diabetes; but which medications work best for Native Americans, for young adults, or for other participant groups?  GRADE has been launched to find answers to those questions.

Type-2 Diabetes is an epidemic that is threatening to become the century’s major public health problem and poses enormous human and economic challenges worldwide. Diabetes is also among the most serious and common conditions for Native Americans, and increasingly for Native American youth – with potential consequences including kidney, heart, and eye diseases as well as nerve damage.

Taking part in clinical trials like GRADE can help improve treatment for Native Americans. 

Most people with diabetes eventually require two medications to control blood glucose levels.  A major challenge for the study is to determine which of several possible medications is best for those already treated with metformin, the most commonly used diabetes medicine.

During GRADE, participants will take metformin as well as a second medication randomly assigned from among four classes of medications, all of which are approved for use with metformin by the FDA.

Volunteers will have their diabetes medications managed free of charge. The study will also include at least four medical visits per year in order to study effects of medication use. Any other healthcare related need will require participants to receive services through their own providers.

GRADE is funded by the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health (NIH).

In the News

The GRADE study is recruiting individuals to participate in the study to determine the best combination drug treatment for Type-2 Diabetes.

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